Basic Information
| Dataset | GSE158909 |
|---|---|
| Status | 2022-06-23 |
| Species | Homo sapiens |
| Source | NCBI GEO |
| Subcellular Localization | cytoplasm|nucleus |
| PMID | 35883037| 36338668 |
| Title | Oxidative stress alters transcript localization of disease-causing genes in the retinal pigment epithelium |
| Citation |
Kaczynski TJ, Au ED, Farkas MH. Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions. BMC Genomics 2022 Jul 26;23(1):539. Kaczynski TJ, Au ED, Farkas MH. Oxidative stress alters transcript localization of disease-associated genes in the retinal pigment epithelium. Mol Vis 2022;28:340-351. |
| Experimental Design | To evaluate the effect of oxidative stress on transcript localization in the retinal pigment epithelium (RPE), we performed poly-A RNA sequencing on nuclear and cytoplasmic fractions from induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) cells exposed to hydrogen peroxide, as well as untreated controls. |
Sample Information
| BioProject | Sample Name | Localization | Treatment | Source | Label |
|---|---|---|---|---|---|
| PRJNA666930 | GSM4815693 | nucleus | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXSnuc1 |
| PRJNA666930 | GSM4815694 | nucleus | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXSnuc2 |
| PRJNA666930 | GSM4815695 | nucleus | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXSnuc3 |
| PRJNA666930 | GSM4815696 | nucleus | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXSnuc4 |
| PRJNA666930 | GSM4815697 | nucleus | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXSnuc5 |
| PRJNA666930 | GSM4815698 | cytoplasm | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXScyto1 |
| PRJNA666930 | GSM4815699 | cytoplasm | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXScyto2 |
| PRJNA666930 | GSM4815700 | cytoplasm | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXScyto3 |
| PRJNA666930 | GSM4815701 | cytoplasm | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXScyto4 |
| PRJNA666930 | GSM4815702 | cytoplasm | none | induced pluripotent stem cell-derived retinal pigment epithelium | BXScyto5 |
| PRJNA666930 | GSM4815703 | nucleus | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2nuc1 |
| PRJNA666930 | GSM4815704 | nucleus | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2nuc2 |
| PRJNA666930 | GSM4815705 | nucleus | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2nuc3 |
| PRJNA666930 | GSM4815706 | nucleus | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2nuc4 |
| PRJNA666930 | GSM4815707 | nucleus | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2nuc5 |
| PRJNA666930 | GSM4815708 | cytoplasm | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2cyto1 |
| PRJNA666930 | GSM4815709 | cytoplasm | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2cyto2 |
| PRJNA666930 | GSM4815710 | cytoplasm | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2cyto3 |
| PRJNA666930 | GSM4815711 | cytoplasm | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2cyto4 |
| PRJNA666930 | GSM4815712 | cytoplasm | 3 hours hydrogen peroxide | induced pluripotent stem cell-derived retinal pigment epithelium | BXSH2O2cyto5 |
Subcellular Localization Number
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Localization Differential Analysis
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Specific Subcellular Localization
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Dynamic RNA Localization
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Specific Enrichment Analysis
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Specific RNA Ratio
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